Changes between Version 1 and Version 2 of Research/LhARA/RadiationBiology/Meetings/2026-05-21


Ignore:
Timestamp:
May 18, 2026, 3:53:17 PM (8 weeks ago)
Author:
ccd24
Comment:

--

Legend:

Unmodified
Added
Removed
Modified
  • Research/LhARA/RadiationBiology/Meetings/2026-05-21

    v1 v2  
    55== Meeting Agenda ==
    66
    7 Plan for PoPLaR
    8 1. Next SCAPA beamtime
     71. Overview of desired paper and required aims for next SCAPA beamtime
    98 - Dates: July/August
    10  - Determine a baseline:
    11   - A baseline of repeating phase 2 cell irradiations was set
    129
    13 2. Aim for October
    14  - Paper
    15   - Aim for a physics publication with reference to the biology results
    16  - Add to Phase 3 plan:
    17   - Comet analysis provides DNA damage results and relatively easy to complete but requires more cell irradiations
    18    - Neutral and alkaline analyses seem the best to study single- and double-strand breaks
    19    - Also see the variation across the cell dish
    20   - Compare this and the clonogenics to the cyclotron irradiation
    21  - Questions to answer:
    22   - Is the spatial variation acceptable?
     102. Steps before next beamtime
    2311
    24 3. Aim for Post-October
    25  - Desired work/papers
    26   - Include IF but it is unnecessary to do in Phase 3 due to the additional irradiations required
    27   - X-ray comparison: Feasible to be included in Phase 3
    28    - Would reproduce the same irradiation conditions (time out of incubator and vertical irradiation) as laser-driven protons
    29  - What do we need to know before we can plan more
    30   - Pre-proton electrons:
    31    - Could explore using the dipoles to remove these
    32    - Have finance for the dipole but need stands so unlikely to be Phase 3
    33   - LET measurement
    34    - LET detector researched but unknown if it will be available for Phase 3
     123. Discussion of aims post-October
     13 - Anything we can do in the next beamtime to build towards these
    3514
    36 4. ELI
    37  - Almost certainly post-October and ran out of time to properly discuss how this can be included in the plan.
     154. Aims for ELI
     16 - Thanks to Emma for coordinating the bid
     17 - Rough dates?
    3818
    39 5. Review steps required
    40  - Plan on Google Doc: https://docs.google.com/document/d/1OTARVtxhLRu02S6CLdRDB2QlGvCqDfZ3aWBifjIFs_Q/edit?usp=sharing
    41  - Steps on Trello: https://trello.com/invite/b/67587c515b0c69656ee78b48/ATTIe86f94b24e3e5884e4cb87e5ed3b89ab64321B83/poplar
    42  - Updates:
    43   - Diagnostics:
    44    - RCF:
    45     - Tony is delaminating some RCF and will compare with the delaminated EBT3 Mark supplied.
    46     - If we provide a batch we will use at SCAPA Tony can test this as well and do the calibration.
    47     - Suggestion that X-ray calibration removes the high-LET saturation effect.
    48     - Marie has offered to do the RCF calibration prior to travelling up
    49    - SciFi:
    50     - Peter has found a source for hollow fibre.
    51      - Cost: £300-400 for 15m, though Peter has money that can be put towards that.
    52      - Could do with a simulation to provide an order of magnitude estimate on the energy deposited on transport fibres
    53     - Tony has offered Birmingham to test the fibres before SCAPA
    54      - Make a package of everything we need and take to Birmingham
    55      - Also, would be able to test using a fibre around the cell dish here
    56       - Keep this simple at the start and just use one fibre
    57   - Bio:
    58    - Could potentially borrow Marie's inverted microscope but depends on other lab users
    59    - Marie is keen to meet up with Jason and Emma to help organise a dry run or testing on the control cell survival
    60 
    61 6. DoNM
     195. DoNM
    6220 - 28/05/26
    6321
    64 7. AoB
    65  - IPAC submitted
     226. AoB
     23
    6624
    6725=== Summary of actions required ===