Changes between Initial Version and Version 1 of Research/DesignStudy/WPMGroup/Meetings/2021/09-02-WP4


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Timestamp:
Sep 4, 2021, 4:18:55 PM (3 years ago)
Author:
dkordopa
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  • Research/DesignStudy/WPMGroup/Meetings/2021/09-02-WP4

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     1'''WP4 Meeting with the Project Office'''
     2
     3Timeline for Project:
     4
     5
     62 yr    design and simulate for LhARA  stage 1: 12MeV in – vitro expts. Standard dish puts bragg peak in cell layer – hence 15MeV target to give ‘headroom’
     7
     8
     95 yr    build for LhARA stage 1. in – vitro expts by biologists proof of principal.
     10Clinical system is longer term. 5+ yrs
     11
     12
     13TPrice
     14•       the 36MeV system in Birmingham produces tracks with bragg peak at approx – 13mm of water.
     15•       12-15MeV tracks will be shorter  ~few mm in water.
     16[[span(style=color: #FF0000, How could one resolve the peak in such a short track? )]]
     17
     18•       Requires high resolution –which in turn requires high frequencies.
     19•       Requires different sensors from higher energy system.
     20From this we conclude
     21•       Lots of challenges for a low energy system.
     22•       Low energy test does not de-risk the high energy system.
     23
     24[[span(style=color: #FF0000,What spatial resolution does the map need to be useful to biologists )]] – **action CW**: to contact JP to ask.
     25
     26[[span(style=color: #FF0000, Does the photoacoustic system with high resolution offer advantages for ‘mini-beam’?)]]
     27
     28Discussion surrounding alternative to BHam and Cern sources @ intermediate energy.
     29•       Medical places are usually 100’s MeV and long pulse.
     30•       TPrice Daresury AVO. 4 stage project – could have been within 2 years – short sharp pulses. Action TP to contact AVO
     31•       Surrey synchrotron – low energy.
     32•       60MeV Clatterbridge. 30mm penetration.
     33•       Clinical centres struggle to get below 70MeV with cyclotrons and dose rate is low.
     34•       Conclude there are no alternatives – apparently LhARA will indeed be unique.
     35
     36Group concludes:
     37
     382 activities are required
     39 
     401.      LhARA consortium proves it has capability to detect a signal – can use any source. This is not a world first, but necessary.
     412.      12-15MeV system design – LhARA phase 1 needs a diagnostic Phase 1 will run for 5-10 years
     42
     43Should simulate beams at low energies. **Action KL**: to adjust C++ code
     44Mechanics of system are also a subject for discussion.