LhARA Project WPM Meeting 6th February 2024 14:00 GMT =

Meeting URL: ​https://strath.zoom.us/j/84550543598?from=addon

Meeting ID: 845 5054 3598 Password: 737274

-------------------------------------------

= Agenda

== Bridging funds

=== K Long - discussion - slides ([raw-attachment:01-2024-02-06-Long.pptx here])

Bridging funds - discussion

Deliverables
Work Package 1. Project management: Deliverables

• '' D1 Early progress review CDR M6 ''
• '' D2 Interim progress review CDR M12 ''
• '' D3 Pre-CDR Review M18 ''
• '' D4 CDR M24 ''

• ''' D5 Initial progress review TDR & technical de-risk update M30 '''
• ''' D6 Interim progress review TDR & technical de-risk update M36 '''
• ''' D7 Final progress review TDR & technical de-risk update M42 '''
• ''' D8 Stage 1 TDR & technical de-risk report M48 '''


• D9 Pre-TDR2 review M54
• D10 TDR2 M60
Milestones

Work package 2: Laser-driven proton and ion source

• '' M2.1: Prediction of optimised proton source parameters for 100+ TW laser systems based on hydrodynamic and kinetic simulations M12 ''
• '' M2.2: First SCAPA ion source simulations and experiment completed M18 ''

• ''' M2.3: Investigation and demonstration of 10 Hz debris and damage challenges at ICL M36 '''
• ''' M2.4: Demonstration of continuous operation of 1 Hz beam generation on SCAPA M48 '''

• M2.5: Demonstration of stabilised 5 Hz beam generation on SCAPA M60

Work package 3: Proton and ion capture

• '' M3.1: Validate plasma simulations with existing Swansea experimental set-up M6 ''
• '' M3.2: Progress report of large diameter plasma experiments and simulations M18 ''

• ''''' M3.3: Next generation plasma lens testbench design M24 '''''

• ''' M3.4: Progress report of standalone plasma apparatus build and commissioning M36 '''
• ''' M3.5: Progress report of large particle-number plasma experiments and simulations M48 '''

• M3.6: Ion focussing results M60
• M3.7: Final plasma lens design M60

=== Radiobiological Science and technology

   Work Package 7: 

 • ''' M7.1: Develop beamline and bespoke facilities at SCAPA for radiobiology experimentation M30 '''
 • ''' M7.2: Preliminary results from cell survival/DNA damage experiments with laser-accelerated protons at SCAPA M36 '''
 • ''' M7.3: Development of RBEs of laser-accelerated protons (versus pre-existing cyclotron-driven protons) in established cell lines M48 '''
 • ''' M7.4: Assessment of DNA damage repair kinetics and immunopeptidomic analysis of laser-accelerated protons M48 '''

   Work package 4: Ion-acoustic dose mapping

    • '' M4.1: Geant4 simulations of beam energy deposition profile M18 ''
    • '' M4.2: Acoustic sensor array design M24 ''

 • ''' M4.3: Iterative reconstruction methods M42 '''
 • ''' M4.4: Integration: ultra-sonic array with radiobiology station M48 ''' may require manpower up-lift and some equipment funds 
 • ''' M4.5: LhARA ion-acoustic test results M48 '''

 Work package 5: Novel end-station development

   • '' M5.1: Design LhARA automated cell dish handling and environmental system M24 ''
   • '' M5.2: Report on end-station user-community consultation M24 ''
   • '' M5.3: Report on end-station component testing at Birmingham M24 ''
   • M5.4: Construct beam delivery room including end-station and cellular imaging capabilities M60
   •  ''M5.5: Specification of LhARA beam monitoring technology M24 ''
   • M5.6: Report on delivery of LhARA beam monitoring system M60
   • '' M5.7: kGy/s tests at Birmingham M24 ''

Work package 6: Design and integration

• '' M6.1: Final review of R&D work towards LhARA CDR M18 ''
• ''' M6.2: Final review of R&D work towards LhARA Phase 1 TDR M42 '''
• ''' M6.3: Review of R&D work towards LhARA Phase 2 TDR M48 '''
• M6.4: Technical report on FFA main magnet prototype M58.
• M6.5: Technical report on MA RF cavity prototype M58.

Work Package 8:

• ''' Creation of collaborative international clinical research group M40 '''
• ''' Wider public engagement - All party parliamentary group on radiotherapy M48 '''

== PA1 

=== Achievements 

- humble bragg competition? 

=== WP5 consultation 3, Jan 24th Liverpool.  Excellent meeting

https://indico.stfc.ac.uk/event/923/?print=1


== AOB