= LhARA radiobiology; meeting: 16Oct25; 14:00 BST = **ZOOM:** https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1 Attended: CW, RW, AFr, EM, BT, TP, JMcG, ND, JP, KL == Meeting Notes == 1. Minutes and actions: - **CD/RW/ND**: Meet to discuss RCF calibration - **Done** - **RW**: Fine-tune installation of cell carousel - **DA**: Sample simulated beamline more frequently - **Done** - **CD**: Investigate defocussing to improve uniformity - **Done** - **CD/RW**: Design RCF holder - **Done** - **KL**: Discuss sparse diagnostic at CLF - **Done** 2. Strathclyde: BT, ED, RW \\ - Processing the RCF from Phase 1 - Proton Number Results: - Collected the source spectrums at 40mm from the laser target - Producing similar numbers of protons as Nick - See an interesting amount of lower energy dose - Not too concerned as expect these to get absorbed in the mylar - See transmission of ~1% for 8-10MeV and 4% for 10MeV - [raw-attachment:LhARA_PoPLaR_RCF_Spectra.pptx Slides] - Robbie to send the spectra to Tony who can pass it through his G4 simulation of the cell dish and return dose rate 3. Simulation CD, DA, AFr: \\ - Results of an Au foil in the beamline with a better source (Afr): - Greatly reduced the CV (Coefficient of Variation) in all cases due to better source - Foil in tube too close to the cells to make a difference - At tube entrance providing possibly the best option at 10.9% - [raw-attachment:Presentation_GoldScatterer_16102025_AFernandez.pdf Slides] - Robbie provided locations of Gold foil: - [raw_attachment:AU_Foil_placement_15102025_v1.pdf Slides] - Results of defocussing the beam - Manage a nice uniformity when only using a 10MeV gaussian - However, when a laser-driven source is inputted a cross reappears - Repeat uniformity tests but using selection of laser-driven spectrum - [raw-attachment:CDyson_Uniformity_via_defocussing.pptx Slides] - Results of 8MeV setup: - Rough results but appears the quads need to be moved closer to the source and closer together - Repeat with selection of laser-driven spectrum - Next minimise CV for best quad and gold foil locations - 2x2cm foil 4. BioPrep EM, JP: \\ - Hoods up and running - Emma sent the risk assessments and cost forms to Mark - Online training to be completed - Check the incubator at SCAPA - Switch on the gas on in the incubator should be 5% - Water from the bottom needs to be distilled - Final confirmation of dates - Week 1: 27/10 - 31/10 - Week 2: 3/11 - 7/11 - Week 3: 17/11 - 21/11 - Next Thursday: LAST possible date for the discussion of the irradiation plan - Contact Marie Boyd? - Yes - Cells need to be fixed and stained - 9 days after irradiating - Diaza is best placed for this - Contact Marie Boyd as well - Discussion Point: Recreate the setup at Birmingham? - Too much effort for what it would tell us - Cyclotron struggles to have a stable beam with less than 12MeV protons 5. Beam Diagnostics KL, CD: \\ - Show RCF holder idea - Has reference to the outer curve of the carousel - Introduce a lip to fix this - Cut the RCF to 0.5mm of the measurements of the holder - Design sent to CLF to be cut - [raw-attachment:RCF_Holder.2.png Slide] - Add Lanex to the outside of the cell dish to check the beam is present - Outer diameter of cell dish is 2.2cm 6. DoNM - Next Week: 23th Oct 7. AoB - Excel sheet complete with shot plan: https://docs.google.com/spreadsheets/d/13vkixxNBZX42WFtxw7_MFJTU-gc06J19N8zpTcMKFys/edit?usp=sharing - If visiting SCAPA please email Robbie and fill it out on the Google excel sheet === Summary of actions === - **RW:** Send proton numbers to Tony to get the dose rate - **CD/DA/Afr:** Find final beam setup with gold foil - **CD:** Find alternative 8MeV setup - **EM/JMcG/DA/more visitors:** Complete the online training indicated by Mark - **CW/RW:** Turn on and clean the water in the incubators - **CW/Most likely to get their attention:** Contact Marie Boyd - **RW:** Add lip to RCF holder ----