= LhARA radiobiology; meeting: 11Dec25; 14:00 BST =

**ZOOM:** https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1 

Attended: JMcG, EM, TP, HO, AG, CD

== Meeting Notes == 

1. Minutes and actions:
 - **MB/EM**: Evaluate the cells
  - **STANDS?**
 - **EM**: Send the cell dishes to SCAPA if required and decide on the shot plan
  - **NOT REQUIRED**
 - **CD, RW, EM, CW ...**: Plan what to run if cells not required. Lay out a clear aim for the rollover days.
  - **NOT REQUIRED**
 - **CD, TP**: Evaluate LET in the cells with the RCF in front
  - **STANDS**
 - **CD, AFr**: Complete analysis of RCF with Error Calculation
  - **STANDS**
 - **AFr, DA**: Write out RCF procedure document
  - **STANDS
 - **TP**: Test orientation of calibration RCF in scanner at Birmingham
  - **DONE**
 - **CD**: Send shot results to Robbie to help find the cause of variation after 8 films irradiated
  - **DONE**

2. SCAPA RW,ED:
 - No Update

3. Bio EM,JP,MB:
 - Marie has just stained the second set of plates and sees colonies in the FaDu but not the HeLa. Birmingham has also reported problems with that HeLa line so it could be an external factor.
 - HeLa cell line not surviving at Birmingham so could be the cell line issue

4. Beamline Diagnostic, TP:
 - Discussion of printing thin (10um) phosphor for scintillation onto a plastic (Mylar)
 - Screenshot of presentation
 - Photodiode outside the outer edge of the cell dish could measure current and therefore intensity, giving an idea of the dose
  - Requires a reprocible beam shape
  - CD to check the consistency of the beam shape

5. Lessons Learnt and Aims for Timeline, CD:
 - Not Discussed

6. In-Person Meeting
 - Date: February?
 - Set up a lettuceMeet

7. DoNM 
- 17th Dec (I will not be able to host)

8. AoB

=== Summary of actions required (so far) ===

 - **CD, TP**: Evaluate LET in the cells with the RCF in front
 - **CD, AFr**: Complete analysis of RCF with errors
 - **RW, CD**: Study correlation between laser diagnostics and mean dose
 - **AFr, DA**: Write out RCF procedure document
 - **EM, JMcG**: Write up summary of PoPLaR Phase 2, including technical summary of cell irradiation procedure
 - **KL, PH**: Investigate other in-beam diagnostics
 - **CD, JMcG**: Investigate how to achieve uniformity without a scatterer in place
 - **CD**: Compare dose profile consistency

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