Changes between Version 3 and Version 4 of Research/LhARA/RadiationBiology/Meetings/2026-02-24

Timestamp:

Mar 2, 2026, 2:26:44 PM (3 months ago)

Author:

ccd24

Comment:

--

Research/LhARA/RadiationBiology/Meetings/2026-02-24

@@ -110 +110 @@
 Josie has completed several simulations varying the number of PMQs and the drifts between the beamline elements. Using Bayesian optimisation and with the restriction that the minimum drift to the first PMQ and the minimum drift between PMQs is 93mm, the best result was in a 2 PMQ setup. Currently running a Bayesian optimisation that releases all the constraints to find the best setup, whether physically feasible or not. We can then probe the restraints that need to be broken to see how flexible they are. 
 
-==== Biology Next Steps =====
+==== Biology Next Steps ====
 
 Aim for good data is 3 independent experiments on 3 different days. The core data would be the survival curves, though this can be supplemented with IF and comet assays. There is also a clear benefit to increasing the number of cell lines being used. 
@@ -124 +124 @@
 
 
-==== Discussion and Summary ====
+=== Discussion and Summary ===
 
 Bio results look better than expected based on the shot-to-shot variation, the cell handling and the variation across the dish. Can improve the cell handling by making a few changes, including reducing the time between shots and not irradiating RCF after the cells. Shot-to-shot variation means that an in-beam diagnostic is required. Spatial variation can be reduced by moving the scatterer closer to the laser target, but hopefully, a better approach using multiple PMQs can be achieved. This is what Josie is investigating with Bayesian Optimisations and studying the ELI beamline. Robbie is going to ELI soon, so that will hopefully help answer any questions.