= LhARA radiobiology; meeting: 19Mar26; 14:00 GMT =

**ZOOM:** https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1 

== Meeting Agenda == 

1. BioPrep
 - EM: Write up of Biology Plan
 - Plan for discussion between Emma, Jason, Marie and Roshine

2. Improving the Beamline
 - JMcG: Simulation of BELLA Beamline
 - Progress on ELI Beamline

3. In-Beam Diagnostic
 - Update on sparse sci-fi
 - Any plan for obtaining a glass sheet?

4. SCAPA Beamline
 - General Update?

5. DoNM 
 - 2nd Apr 14:00

6. AoB 

== Meeting Notes == 

1. BioPrep
 - Discussion of funding: excess LhARA funds to be spent on bio equipment for SCAPA. Plan being developed on how to utilise these funds.
 - Emma to present plan for PoPLaR Tuesday 24th LhARA collaboration meeting. 
 - Discussion of using Marie's lab and using x-ray irradiator as control, perhaps also suspending the dishes for the same amount of time out of the incubator so that the only difference is particles.

2. Improving the Beamline
 - JMcG: Simulation of BELLA source by using a spectrum provided of the beam at 52 mm on an RCF- Beamline. [raw-attachment:BELLA-source-simulations.pdf Slides]
 - Source characterisation looks promising, having issues with rest of the beam, losing a lot of particles. 
 - Plan to run linear optics and BDSIM side by side to check each component.
 - Plan to do the same for Eli.

3. In-Beam Diagnostic
 - Sci-fi planes at the workshop waiting on filing.
 - To do initial measurements 30th March.
 - Masters students joining for a few months- plan to do experiment with sci-fi planes: counting photons with UV source.


=== Summary of actions required ===

In-Beam Diagnostics
- **RW, CD**: Study correlation between laser diagnostics and mean dose
- **CD, TP**: Refine evaluations of LET in the cells with the RCF in front
- **CD**: Predict the cell dish dose from the RCF in front of it
- **PH**: Investigate how to get the light out of the vacuum chamber
- Investigate how a phosphor sheet could be incorporated into the design
- Acquire a glass sheet

Bio Next Steps
- **EM**: Write up a biology plan
 - Decide whether to use Marie's lab and whether to stick with HeLa
- **EM, MB, JP, RA**: Meet to finalise details
- **Unassigned**: Obtain an inverted microscope
- **Unassigned**: Run controls to examine how long the cells can survive vertically

Improve the spatial variation
- Decide the energy we should be optimising for
 - **RW**: Examine energy spectra variation
 - Find LET for different energies in the cell dish

Other Beamlines
- **JMcG**: Simulate BELLA
- **JMcG**: Talk to ELI people and simulate ELI
- Build a bid towards ELI

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