LhARA radiobiology; meeting: 19Mar26; 14:00 GMT

ZOOM: ​https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1

Meeting Agenda

1. BioPrep
   • EM: Write up of Biology Plan
   • Plan for discussion between Emma, Jason, Marie and Roshine

2. Improving the Beamline
   • JMcG: Simulation of BELLA Beamline
   • Progress on ELI Beamline

3. In-Beam Diagnostic
   • Update on sparse sci-fi
   • Any plan for obtaining a glass sheet?

4. SCAPA Beamline
   • General Update?

5. DoNM
   • 2nd Apr 14:00

6. AoB

Meeting Notes

1. BioPrep
   • Discussion of funding: excess LhARA funds to be spent on bio equipment for SCAPA. Plan being developed on how to utilise these funds.
   • Emma to present plan for PoPLaR Tuesday 24th LhARA collaboration meeting.

2. Improving the Beamline
   • JMcG: Simulation of BELLA source by using a spectrum provided of the beam at 52 mm on an RCF- Beamline. BELLA-source-simulations.pdf
   • Source characterisation looks promising, having issues with rest of the beam, losing a lot of particles.
   • Plan to run linear optics and BDSIM side by side to check each component.
   • Plan to do the same for Eli.

3. In-Beam Diagnostic
   • Sci-fi planes at the workshop waiting on filing.
   • To do initial measurements 30th March.
   • Masters students joining for a few months- plan to do experiment with sci-fi planes: counting photons with UV source.

Summary of actions required

In-Beam Diagnostics

• RW, CD: Study correlation between laser diagnostics and mean dose
• CD, TP: Refine evaluations of LET in the cells with the RCF in front
• CD: Predict the cell dish dose from the RCF in front of it
• PH: Investigate how to get the light out of the vacuum chamber
• Investigate how a phosphor sheet could be incorporated into the design
• Acquire a glass sheet

Bio Next Steps

• EM: Write up a biology plan
  • Decide whether to use Marie's lab and whether to stick with HeLa
• EM, MB, JP, RA: Meet to finalise details
• Unassigned: Obtain an inverted microscope
• Unassigned: Run controls to examine how long the cells can survive vertically

Improve the spatial variation

• Decide the energy we should be optimising for
  • RW: Examine energy spectra variation
  • Find LET for different energies in the cell dish

Other Beamlines

• JMcG: Simulate BELLA
• JMcG: Talk to ELI people and simulate ELI
• Build a bid towards ELI

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