Changes between Version 2 and Version 3 of Research/LhARA/RadiationBiology/Meetings/2026-04-16


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Timestamp:
Apr 16, 2026, 4:14:40 PM (5 weeks ago)
Author:
ccd24
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  • Research/LhARA/RadiationBiology/Meetings/2026-04-16

    v2 v3  
    66
    771. BioPrep
    8  - General Update
     8 - No Major Updates
     9 - Need to deal with cell survival problem
     10 - Emma might have a new timing to show max cell survival time
     11 - Calvin to put together a list of suggestions to improve cell survival
    912
    10132. SCAPA Beamline
    11  - General Update
     14 - No major update
     15 - A few things have been removed from the beamline
     16 - Robbie plans on sending out some things to Josie and I
    1217
    13183. In-Beam Diagnostic
    14  - CD: Summary of Results using delam RCF
     19 - Scifi to be tested next Wednesday 22nd
     20 - Tony has a physical camera for his diagnostics
     21 - Robbie has been talking with a company called Advacam which do detectors for LET
     22  - Would have to be placed instead of the cells
     23  - May have a minimum of 15MeV
     24  - Cost is between 8,700 and 12,100 euros without VAT
     25  - Peter has used these at QMUL
     26 - Delaminated EBT3 RCF can no longer be ordered
     27  - Mark still has some sheets if necessary
    1528
    16294. Improving the Beamline
    1730 - CD: LET plots for different energies
     31  - [raw-attachment:
     32  - Minimum Energy required to reach the cells is 3MeV with 10um Cu scatterer and 2.5MeV without the scatterer
     33  - The minimum energy to aim for should be 7MeV
     34  - Hard limit to avoid protons with an energy less than 5MeV. With a scatterer in place, this should be more like 5.5MeV
     35  - Therefore, the limits of the energy distribution, if described as a Gaussian, should be centred on 7MeV with a maximum standard deviation of 0.7MeV
     36  - Based on pre-cells, 4MeV is the hard cut-off for protons before entering cells.
     37
     38
    1839
    19405. Collaboration Meeting
     
    2142 - Presentations
    2243 - https://indico.stfc.ac.uk/event/1783/
     44
     45Presentation should also include the next steps for making a publication
     46
     47
     48Think through the programme we should be executing from October and a couple of years and include ELIMED, including development of SCAPA
     49
     50Reference data and how we can collect that
     51Do we want to compare with electrons
     52Marie has an interest in this as well
     53Why compare with electrons
     54X-rays are a transport for electrons
     55Compare with VHEE electrons where LETs is less than X-rays
     56What is the specific question that is being addressed
     57Bio results usually have 10% error
     58
     59Robbie not avilable and Ben is also gone. Discuss talks to be done
    2360
    24616. IPAC Contribution
     
    3067
    31686. AoB
     69
     70ELIMED proposal
     71Discussion needed to help answer ELIMED's questions
     72One of them was that no clear distinction from LhARA
     73Reliant on their faciliteis. Is there a facility nearby we can use?
     74Hold a meeting to discuss ELIMED's questions and how to answer them
     75Robbie might know someone local
     76
     77Could take bio to the building
     78Portable incubators
     79Take a centrifuge
     80Portable flow hood
     81
     82Also if we do DNA damage response
     83
     84Deadline is 22nd April
     85
     86https://up.eli-laser.eu/call/8th-call-for-users-5pk2js
     87
     88https://up.eli-laser.eu/instrument/elimaia-AyTTqw
     89
     90Emma is the corrindator for this
     91
    3292
    3393=== Summary of actions required ===
     
    44104
    45105Bio Next Steps
    46 - **EM**: Write up a biology plan
     106- **EM**: Write up technical summary of Phase 2
     107- **EM**: Write up a future biology plan
    47108 - Decide whether to use Marie's lab and whether to stick with HeLa
    48109- **EM, MB, JP, RA**: Meet to finalise details
     110- **CD**: Gather ideas for improving cell survival
    49111- **Unassigned**: Obtain an inverted microscope
    50112- **Unassigned**: Obtain multi-chamber haemocytometers (Might be able to use Birmingham's)