= LhARA radiobiology; meeting: 23Jul26; 14:00 GMT =

**ZOOM:** https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1 

== Agenda == 

1. Long-term LhARA Biology Plan
 - JMcG&KL: Presentation
 - General Discussion

2. Overview of Current SCAPA Plan 
 - Solutions to the three main problems:
  - Move the scatterer further up the beamline (closer to the laser-target).
  - Use a real-time diagnostic
  - Investigate how long the cells survive and the cause of death
 - Additions:
  - Collect more biology results?
 - When?:
  - Robbie mentioned February
  - Need to be ready to latch onto any downtime of other experiments
 - More information: https://docs.google.com/document/d/1OTARVtxhLRu02S6CLdRDB2QlGvCqDfZ3aWBifjIFs_Q/edit?tab=t.0
 - Steps required: Below and at https://trello.com/invite/b/67587c515b0c69656ee78b48/ATTIe86f94b24e3e5884e4cb87e5ed3b89ab64321B83/poplar

3. Instrumentation Discussion
 - Options:
  - Sparse scintillating fibre arrays in the vacuum chamber
  - Scintillating fibre around the cell dish
  - Lanex around the cell dish
  - Integrated Current Transformers (ICTs)
  - Laser Diagnostics (Backscatter etc)
  - Replace the scatterer with a scintillating sheet
  - (RCF around the cell dish (if desperate))
 - Testing method:
  - Calibrate with RCF?
  - No calibration. Use lots of cell dishes and match the distribution of variation in diagnostic output to the "known" distribution of the shot-to-shot variation
 - LET Detector

4. BioPrep Discussion
 - Spatial Variation: Is a CV of 8% acceptable?
 - Cell Control Survival:
  - Need to test how long cells can remain vertical
  - Can reduce the time taken to conduct the irradiations (and therefore the time the cells are vertical for)
  - Monitor the temperature of the thermostat
 - Better instrumentation:
  - Inverted microscope
  - Multi-chamber haemocytometer
 - More results (as well as clonogenics):
  - Comet analyses
  - X-ray comparison on-site

5. Alternate Beamlines
 - ELI Rejected
  - Waiting for feedback

6. Discussion on Ion-Acoustic Plan
 - Current updates

7. DoNM 
 - 06/08/26

8. AoB


=== Summary of actions required ===

In-Beam Diagnostics
- **Unassigned**: Acquire a glass sheet
- **Unassigned**: Get a new RCF batch and calibrate
- **TP**: Testing delaminating EBT3
- **PH**: Obtain transparent fibre or an alternative method for light transport
- **PH**: Obtain a lens for hollow fibre tests
- **CD**: Simulate energy deposited in transport fibres
- **KL, CD, JMcG, PH**: Design a system to make full scifi prototypes
- **KL, CD, JMcG, PH**: Make a full scifi prototype
- **KL, CD, JMcG, PH**: Discuss visit to Birmingham to test SciFi
- **RW, CD**: Study the correlation between laser diagnostics and mean dose
- **Unassigned**: Investigate how a phosphor sheet could be incorporated into the design of the cell dish
- **CW**: Investigate the feasibility of ICTs for our beamline
- **MH**: Investigate LET detector

Bio Next Steps
- **EM, CD, JMcG**: Write up technical summary of Phase 2
- **EM**: Write up a biology plan for a 2 PMQ setup
- **Unassigned**: Obtain an inverted microscope
- **Unassigned**: Obtain multi-chamber haemocytometers (Might be able to use Birmingham's)
- **Unassigned**: Obtain a thermostat for the incubator
- **MB, JP, MB**: Meet up to plan cell survival dry run and a bio plan for a 2 Quad setup
- **EM**: Run controls to examine how long the cells can survive vertically

Beamline Modelling
- **CD**: Examine energy spectra variation
- **RW, CD**: Source characterisation

Alternate Beamlines
- **JMcG**: Simulate BELLA
- **JMcG**: Simulate ELI

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