LhARA Radiobiology Meeting: 01Oct26; 14:00 BST

ZOOM: ​https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1

• Planning Document: ​https://docs.google.com/document/d/1OTARVtxhLRu02S6CLdRDB2QlGvCqDfZ3aWBifjIFs_Q/edit?tab=t.0

• Trello: ​https://trello.com/invite/b/67587c515b0c69656ee78b48/ATTIe86f94b24e3e5884e4cb87e5ed3b89ab64321B83/poplar

Attended: KL, MH, CW, TP, SdL, PB, RH, RA, FA, CD

Meeting Notes

1. Alternate Beamlines
   • ELIMED part of the next ELI submission
     • There appear to be calls for ELIMED every year
   • 20th October 12:00 (noon)
     • Unlikely to make this deadline
     • Cannot make a submission repeating the same missing details
   • BUT:
     • Calvin to share the document
     • Ken and Josie to nudge the bioplan into action

2. BioPrep
   • Alex seen SCAPA
     • Yes and transwells have been agreed to be the best way forward
   • Transwells
     • Cost ~£1000
   • February puts the bio team on a timetable
   • Need a stronger bio/SCAPA presence at these meetings
     • Colin to reach out to Marie
     • Colin to reach out to the SCAPA team to confirm February is our goal

3. Instrumentation
   • RCF
     • Updates on delaminated EBT4
       • No longer sold unless for 100 boxes or more
       • Need 35 more boxes to get an order
     • Mark found a different type of film
       • Tony has requested a free sample to check it out
       • Tony has two master's students on cmos and can compare to the new film
   • SciFi
     • Construction pad is built
     • Appears to be no sensitivity to rotation of the array (as expected)
   • Thin wall ion chamber
     • On-line detector uses protons
     • Thin window (10s of um of Mylar)
     • Concern is mainly recombination at the time of ionisation because of the intense pulse
       • Will still see a residual ionisation
   • Diamond detector
     • Off-line using the electrons
     • Need a better understanding of the electrons to understand its feasibility
   • Richard to discuss thin wall detectors and diamond detectors at a Tuesday meeting
   • Calorimeter
     • Measure the energy by measuring the temperature change in graphite
     • Most stable and understood measure of dose
     • If we had £10K can ask the same company NPL asked to make a transcal detector thin enough for our energies
     • Sam Flynn's detector that has been discussed before
     • Longer term benefit is thatthey're known compared with something like air fluoresence which is not as well known
   • Further discussion:
     • Need to group these diagnostics into:
       • In-beam beamline diagnostics
       • Dosimetry run at the same time as cells. Measuring the dose in the cells. eg ion-acoustic
       • Measuring the dose of the low-energy beams to establish stability
     • As always, beamtime available in Birmingham
       • Ken, Simon, Calvin and Josie to discuss next week

4. SCAPA
   • Updates
     • No update

5. Review Trello: ​https://trello.com/invite/b/67587c515b0c69656ee78b48/ATTIe86f94b24e3e5884e4cb87e5ed3b89ab64321B83/poplar

6. DoNM
   • 15/10/26

7. AoB

• Funds
  • Have £5k
  • Ken meeting this afternoon to discuss £14k Imperial money

Summary of actions required

In-Beam Diagnostics

• Unassigned: Acquire a glass sheet
• Unassigned: Get a new RCF batch and calibrate
• SdL: Simulate energy deposited in transport fibres
• KL, CD, JMcG, SdL: Design a system to make full scifi prototypes
• KL, CD, JMcG, SdL: Make a full scifi prototype
• KL, CD, JMcG, SdL: Discuss visit to Birmingham to test SciFi
• RW, CD: Study the correlation between laser diagnostics and mean dose
• CW: Investigate the feasibility of ICTs for our beamline
• MH: Investigate LET detector
• CW: Ask Narender about air fluorescence implementation
• JMcG: Investigate using IF as a dosimeter
• GS, RH: Investigate fast electron diagnostic
• TP: Investigating commerical delaminated EBT4

Bio Next Steps

• EM, CD, JMcG: Write up technical summary of Phase 2
• EM, MB, RA, JMcG: Write up a biology plan for a 2 PMQ setup
• Unassigned: Obtain an inverted microscope
• Unassigned: Obtain multi-chamber haemocytometers (Might be able to use Birmingham's)
• Unassigned: Obtain a thermostat for the incubator
• EM: Send cells to Rosh and Marie
• EM, MB, RA, JMcG: Run controls to examine how long the cells can survive vertically
• CW, AM: Show Alex around SCAPA
• MB, RA: Send specifications of and transwells to Tony to test at Birmingham
  • DONE
• MB, RA: Test transwells with x-rays
• KL: Share paper with interesting cell dishes (RCF sandwich)
  • DONE

Beamline Modelling

• Unassigned: Investigate how to improve the beamline beyond CV=8%
  • DONE
• CD: Examine energy spectra variation
• JMcG, ED: Discuss spectra fits and SCAPA source divergence
• JMcG: Talk to Darsebury to get more information on sensible dipole parameters
  • DONE

Alternate Beamlines

• JMcG: Simulate BELLA
• JMcG: Simulate ELI
• CD: Planning doc for ELI

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