LhARA radiobiology; meeting: 09Jul26; 14:00 GMT

ZOOM: ​https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1

Attended: KL, CW, CD, (JB)

Meeting Notes

1. General Discussion
   • Robbie mentioned that beamtime might be more likely in February.
   • Colin believes we might be able to get some time in Autumn if we can time it correctly with other beamtime.
   • There is work where the SCAPA team are using AI and looking at the variability of the laser.
   • Colin to discuss with Robbie how to build the setup with another experiment

2. Instrumentation
   • General
     • Colin suggested filling the carousel and running 1 shot then repeating with 2 shots etc
     • Each cell dish would have Lanex around it or something for real-time measurement
     • Then we could skip the calibration stage by comparing the variation in the Lanex signal with the known variation in dose
     • Problems involve the number of cells needing to be collected and the time that would take
     • Needs discussion with bio team
   • SciFi
     • Need to actually test whether the transporting fibre will scintillate
     • Operate on the assumption it does not
     • If it does Peter has ordered hollow-fibre
     • Might be able to use a standrad fibre-optic connector
   • ICT
     • Colin has ICTs
     • 3-5ns rise time, so should see the short pulses but on the edge of visible and may be blurred out
     • 0.1V in signal per Amp in beam current
     • Beam would also need to be roughly symmetric, so has to be after the scatterer
     • There is also a smaller, more sensitive ICT we could use
     • Also possibilities with 3D printing

3. Overview of Trello
   • Reminder plan is laid out in the google doc and can be changed
   • Trello: ​https://trello.com/invite/b/67587c515b0c69656ee78b48/ATTIe86f94b24e3e5884e4cb87e5ed3b89ab64321B83/poplar
   • Planning next SCAPA Document: ​https://docs.google.com/document/d/1OTARVtxhLRu02S6CLdRDB2QlGvCqDfZ3aWBifjIFs_Q/edit?usp=sharing

4. DoNM
   • 23/07/26

5. AoB

Summary of actions required

In-Beam Diagnostics

• Unassigned: Acquire a glass sheet
• Unassigned: Get a new RCF batch and calibrate
• TP: Testing delaminating EBT3
• PH: Obtain transparent fibre or an alternative method for light transport
• PH: Obtain a lens for hollow fibre tests
• CD: Simulate energy deposited in transport fibres
• KL, CD, JMcG, PH: Design a system to make full scifi prototypes
• KL, CD, JMcG, PH: Make a full scifi prototype
• KL, CD, JMcG, PH: Discuss visit to Birmingham to test SciFi
• RW, CD: Study the correlation between laser diagnostics and mean dose
• Unassigned: Investigate how a phosphor sheet could be incorporated into the design of the cell dish
• CW: Investigate the feasibility of ICTs for our beamline

Bio Next Steps

• EM, CD, JMcG: Write up technical summary of Phase 2
• EM: Write up a biology plan for a 2 PMQ setup
• Unassigned: Obtain an inverted microscope
• Unassigned: Obtain multi-chamber haemocytometers (Might be able to use Birmingham's)
• Unassigned: Obtain a thermostat for the incubator
• MB, JP, MB: Meet up to plan cell survival dry run and a bio plan for a 2 Quad setup
• EM: Run controls to examine how long the cells can survive vertically

Beamline Modelling

• CD: Examine energy spectra variation
• RW, CD: Source characterisation

Alternate Beamlines

• JMcG: Simulate BELLA
• JMcG: Simulate ELI

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