Changes between Version 2 and Version 3 of Research/LhARA/RadiationBiology/Meetings/2025-10-16

Timestamp:

Oct 16, 2025, 4:30:40 PM (4 days ago)

Author:

ccd24

Comment:

--

Research/LhARA/RadiationBiology/Meetings/2025-10-16

@@ -3 +3 @@
 **ZOOM:** https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1 
 
-== Agenda == 
+Attended: CW, RW, AFr, EM, BT, TP, JMcG, ND, JP
+
+== Meeting Notes == 
 
 1. Minutes and actions:
 - **CD/RW/ND**: Meet to discuss RCF calibration
  - **Done**
-- **RW**: Send TP RCF data
- - **Done?**
 - **RW**: Fine-tune installation of cell carousel
 - **DA**: Sample simulated beamline more frequently
  - **Done**
 - **CD**: Investigate defocussing to improve uniformity
- - **Stands**
+ - **Done**
 - **CD/RW**: Design RCF holder
  - **Done**
@@ -22 +22 @@
 2. Strathclyde: BT, ED, RW \\
 - Processing the RCF from Phase 1
- - Proton Number Results
-  - Organise Robbie, Emma and Jason to discuss the irradiation plan
-- Beamline setup
- - New minimum distance between Quads?
- - Cell carousel fine-tuning update
+ - Proton Number Results:
+  - Collected the source spectrums at 40mm from the laser target
+  - Producing similar numbers of protons as Nick
+  - See an interesting amount of lower energy dose
+   - Not too concerned as expect these to get absorbed in the mylar
+  - See transmission of ~1% for 8-10MeV and 4% for 10MeV
+  - Robbie to send the spectra to Tony who can pass it through his G4 simulation of the cell dish and return dose rate
+  - Slides?
 
 3. Simulation CD, DA, AFr: \\
-- Results of an Au foil in the beamline with a better source
-- Results of defocussing the beam (If completed)
-- Results of 8MeV quad positioning
+- Results of an Au foil in the beamline with a better source (Afr):
+ - Greatly reduced the CV (Coefficient of Variation) in all cases due to better source
+ - Foil in tube too close to the cells to make a difference 
+ - At tube entrance providing possibly the best option at 10.9%
+ - Slides?
+- Results of defocussing the beam 
+ - Manage a nice uniformity when only using a 10MeV gaussian
+ - However, when a laser-driven source is inputted a cross reappears
+ - Repeat uniformity tests but using selection of laser-driven spectrum
+ - Slides?
+- Results of 8MeV setup:
+ - Rough results but appears the quads need to be moved closer to the source and closer together
+ - Repeat with selection of laser-driven spectrum
+- Next minimise CV for best quad and gold foil locations
+ - 2x2cm foil
 
 4. BioPrep EM, JP: \\
 - Hoods up and running
-- Dry-run update
+ - Emma sent the risk assessments and cost forms to Mark
+ - Online training to be completed
+- Check the incubator at SCAPA
+ - Switch on the gas on in the incubator should be 5%
+ - Water from the bottom needs to be distilled
 - Final confirmation of dates
+ - Week 1: 27/10 - 31/10
+ - Week 2: 3/11 - 7/11
+ - Week 3: 17/11 - 21/11
+ - Next Thursday: LAST possible date for the discussion of the irradiation plan
+- Contact Marie Boyd? - Yes
+- Cells need to be fixed and stained - 9 days after irradiating
+ - Diaza is best placed for this
+ - Contact Marie Boyd as well
+
+- Discussion Point: Recreate the setup at Birmingham?
+ - Too much effort for what it would tell us
+ - Cyclotron struggles to have a stable beam with less than 12MeV protons
 
 5. Beam Diagnostics KL, CD: \\
 - Show RCF holder idea
- - Show new design
- - Organise to get the RCF cut
-- Ken update on a sparse beam diagnostic?
+ - Has reference to the outer curve of the carousel
+ - Introduce a lip to fix this
+ - Cut the RCF to 0.5mm of the measurements of the holder
+ - Design sent to CLF to be cut
+- Add Lanex to the outside of the cell dish to check the beam is present
+ - Outer diameter of cell dish is 2.2cm
 
 6. DoNM 
-- 30th October
+- Next Week: 23th Oct
 
 7. AoB
-- Excel sheet complete with shot plan
+- Excel sheet complete with shot plan: https://docs.google.com/spreadsheets/d/13vkixxNBZX42WFtxw7_MFJTU-gc06J19N8zpTcMKFys/edit?usp=sharing
+- If visiting SCAPA please email Robbie and fill it out on the Google excel sheet
 
 
 === Summary of actions ===
+**RW:** Send proton numbers to Tony to get the dose rate
+**CD/DA/Afr:** Find final beam setup with gold foil
+**CD:** Find alternative 8MeV setup
+**EM/JMcG/DA/more visitors:** Complete the online training indicated by Mark
+**CW/RW:** Turn on and clean the water in the incubators
+**CW/Most likely to get their attention:** Contact Marie Boyd
+**RW:** Add lip to RCF holder
+
+
+