LhARA radiobiology; meeting: 28May26; 14:00 GMT

ZOOM: ​https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1

Attended: PH, JMcG, AFr, MH, JPi, CD

Meeting Notes

1. Overview of desired paper and required aims for next SCAPA beamtime
   • Dates: July/August

2. Steps before next beamtime and discussion
   • Document: ​https://docs.google.com/document/d/1OTARVtxhLRu02S6CLdRDB2QlGvCqDfZ3aWBifjIFs_Q/edit?usp=sharing
   • Do we have a set beamtime?
   • Cell control tests should be done with irradiated cells as well
     • Can use Marie's lab
   • Mark has a Timepix detector to use as an alpha-particle detector and OSL he will test.
     • If successful, can bring to SCAPA as LET detectors

3. Discussion of aims post-October

4. Aims for ELI
   • Thanks to Emma for coordinating the bid
   • Josie requires more details on the low energy beams at ELI. Currently, can only find information on the 68MeV beams.
     • Calvin to ask Robbie tomorrow.

5. Quick updates
   • In-beam diagnostic
     • PH: Presentation on hollow fibre readout plan
       • Slides
       • Peter has ordered some plastic silicone fibre with hollow core.
       • Zemax simulations show a fibre with a 1.6mm core has 0.14% to ~1m away.
       • Bending must be constant so require tubing and stands to hold the fibres in place
       • Must consider the 10mm thick glass porthole
       • Need the dimensions of the vacuum chamber to be able to recreate and test at Imperial
   • Bioprep
     • None
   • SCAPA
     • None

6. Trello
   • Review: ​https://trello.com/invite/b/67587c515b0c69656ee78b48/ATTIe86f94b24e3e5884e4cb87e5ed3b89ab64321B83/poplar

7. DoNM
   • 11/06/26

8. AoB

Summary of actions required

In-Beam Diagnostics

• Unassigned: Acquire a glass sheet
• Unassigned: Get a new RCF batch and calibrate
• PH: Investigate how to get the light out of the vacuum chamber
• CD: Simulate energy deposited in transport fibres
• KL, CD, JMcG, PH: Make a full scifi prototype
• KL, CD, JMcG, PH: Discuss visit to Birmingham to test SciFi
• RW, CD: Study correlation between laser diagnostics and mean dose
• Unassigned: Investigate how a phosphor sheet could be incorporated into the design of the cell dish

Bio Next Steps

• EM, CD, JMcG: Write up technical summary of Phase 2
• EM: Write up a biology plan for a 2 PMQ setup
• Unassigned: Obtain an inverted microscope
• Unassigned: Obtain multi-chamber haemocytometers (Might be able to use Birmingham's)
• MB, JP, MB: Meet up to plan cell survival dry run
• EM: Run controls to examine how long the cells can survive vertically

Beamline Modelling

• RW: Examine energy spectra variation
• RW, CD: Source characterisation

Other Beamlines

• JMcG: Simulate BELLA
• JMcG: Simulate ELI

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