LhARA Radiobiology Meeting: 06Aug26; 14:00 BST

ZOOM: ​https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1

• Planning Document: ​https://docs.google.com/document/d/1OTARVtxhLRu02S6CLdRDB2QlGvCqDfZ3aWBifjIFs_Q/edit?tab=t.0

• Trello: ​https://trello.com/invite/b/67587c515b0c69656ee78b48/ATTIe86f94b24e3e5884e4cb87e5ed3b89ab64321B83/poplar

Meeting Notes

1. BioPrep

• Josie: Summary of last week's biology meeting- Bio plan being prepped short- and long-term, covering both experiments within our existing collaboration remit and ways to expand the team/bring in outside experts. Jason and Emma have mapped internal biological experiments comparing radiation source results from cells to organoids to animals (see Emma's RAL lecture). Plan to hold a seminar day with the wider field to showcase LhARA, discuss overlapping work, and identify partners suited to joining LhARA or collaborating. Further meetings needed to nail down specifics for both the seminar and near-term experiments.

2. Instrumentation

• RCF:
  • Tony investigated delaminated EBT3 as a thinner alternative for dosimetry (minimal dose interference) but couldn't source it. Discussed manufacturing our own instead. Marie flagged that Alexander Mullen works on polymer thinning/stretching — plan to meet him to discuss making a thin sheet to sit in front of the cells without significantly reducing dose. Also agreed to reach out to NPL: Richard G. will connect with Giuseppe to discuss their similar process. Richard also mentioned the benefit in looking at fast electrons and will report back findings at the next meeting.
• Scifi:
  • Unlikely to get clear fibre to Robbie before he goes to ELI and want to test it at Birmingham first
  • Equipment currently at Queen Mary's (Ken talking to them)
• Air Scintillation
  • Colin/Narendar: Planning to meet to discuss the feasibility of the implementation at SCAPA and the timeframe

3. SCAPA

• Team busy- no updates this week

4. Alternate Beamlines
   • No ELI feedback yet

5. Review Trello: ​https://trello.com/invite/b/67587c515b0c69656ee78b48/ATTIe86f94b24e3e5884e4cb87e5ed3b89ab64321B83/poplar

6. DoNM
   • 20/08/26

7. AoB

Summary of actions required

In-Beam Diagnostics

• Unassigned: Acquire a glass sheet
• Unassigned: Get a new RCF batch and calibrate
• TP: Testing delaminating EBT3
• PH: Obtain transparent fibre or an alternative method for light transport
• PH: Obtain a lens for hollow fibre tests
• CD: Simulate energy deposited in transport fibres
• KL, CD, JMcG, PH: Design a system to make full scifi prototypes
• KL, CD, JMcG, PH: Make a full scifi prototype
• KL, CD: Send clear fibre to SCAPA before 16th August (Contact Ewan or Colin since Robbie is USA)
• KL, CD, JMcG, PH: Discuss visit to Birmingham to test SciFi
• RW, CD: Study the correlation between laser diagnostics and mean dose
• Unassigned: Investigate how a phosphor sheet could be incorporated into the design of the cell dish
• CW: Investigate the feasibility of ICTs for our beamline
• MH: Investigate LET detector
• CW: Ask Narender about air fluorescence implementation
• JMcG: Investigate using IF as a dosimeter

Bio Next Steps

• EM, CD, JMcG: Write up technical summary of Phase 2
• EM: Write up a biology plan for a 2 PMQ setup
• Unassigned: Obtain an inverted microscope
• Unassigned: Obtain multi-chamber haemocytometers (Might be able to use Birmingham's)
• Unassigned: Obtain a thermostat for the incubator
• EM: Run controls to examine how long the cells can survive vertically
• JMcG: Plan a test of vertical cell survival using Emma/Jason's HeLa cell line and Marie's cell line
• JMcG: Produce a HeLa colony that can survive on Mylar

Beamline Modelling

• Unassigned: Investigate how to improve the beamline beyond CV=8%
• CD: Examine energy spectra variation
• RW, CD: Source characterisation

Alternate Beamlines

• JMcG: Simulate BELLA
• JMcG: Simulate ELI

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