LhARA Radiobiology Meeting: 06Aug26; 14:00 BST

ZOOM: ​https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1

• Planning Document: ​https://docs.google.com/document/d/1OTARVtxhLRu02S6CLdRDB2QlGvCqDfZ3aWBifjIFs_Q/edit?tab=t.0

• Trello: ​https://trello.com/invite/b/67587c515b0c69656ee78b48/ATTIe86f94b24e3e5884e4cb87e5ed3b89ab64321B83/poplar

Meeting Notes

1. BioPrep

• Josie: Summary of last week's biology meeting:
  • Bio plan being prepped short- and long-term, covering both experiments within our existing collaboration remit and ways to expand the team/bring in outside experts.
  • Jason and Emma have mapped internal biological experiments comparing radiation source results from cells to organoids to animals (see Emma's RAL lecture).
  • Plan to hold a seminar day with the wider field to showcase LhARA, discuss overlapping work, and identify partners suited to joining LhARA or collaborating.
  • Further meetings needed to nail down specifics for both the seminar and near-term experiments.

2. Instrumentation

• RCF:
  • Tony investigated delaminated EBT3 as a thinner alternative for dosimetry (minimal dose interference) but couldn't source it. Discussed manufacturing our own instead.
  • Marie flagged that Alexander Mullen works on polymer thinning/stretching — plan to meet him to discuss making a thin sheet to sit in front of the cells without significantly reducing dose.
  • Also agreed to reach out to NPL: Richard G. will connect with Giuseppe to discuss their similar process.
  • Richard also mentioned the benefit in looking at fast electrons and will report back findings at the next meeting.
• Scifi:
  • Unlikely to get clear fibre to Robbie before he goes to ELI and want to test it at Birmingham first
  • Equipment currently at Queen Mary's (Ken talking to them)
• Air Scintillation
  • Colin/Narendar: Planning to meet to discuss the feasibility of the implementation at SCAPA and the timeframe

3. SCAPA

• Team busy- no updates this week

4. Alternate Beamlines
   • No ELI feedback yet

5. Review Trello: ​https://trello.com/invite/b/67587c515b0c69656ee78b48/ATTIe86f94b24e3e5884e4cb87e5ed3b89ab64321B83/poplar

6. DoNM
   • 20/08/26

7. AoB

Summary of actions required

In-Beam Diagnostics

• Unassigned: Acquire a glass sheet
• Unassigned: Get a new RCF batch and calibrate
• TP: Testing delaminating EBT3
• PH: Obtain transparent fibre or an alternative method for light transport
• PH: Obtain a lens for hollow fibre tests
• CD: Simulate energy deposited in transport fibres
• KL, CD, JMcG, PH: Design a system to make full scifi prototypes
• KL, CD, JMcG, PH: Make a full scifi prototype
• KL, CD: Send clear fibre to SCAPA before 16th August (Contact Ewan or Colin since Robbie is USA)
• KL, CD, JMcG, PH: Discuss visit to Birmingham to test SciFi
• RW, CD: Study the correlation between laser diagnostics and mean dose
• Unassigned: Investigate how a phosphor sheet could be incorporated into the design of the cell dish
• CW: Investigate the feasibility of ICTs for our beamline
• MH: Investigate LET detector
• CW: Ask Narender about air fluorescence implementation
• JMcG: Investigate using IF as a dosimeter

Bio Next Steps

• EM, CD, JMcG: Write up technical summary of Phase 2
• EM: Write up a biology plan for a 2 PMQ setup
• Unassigned: Obtain an inverted microscope
• Unassigned: Obtain multi-chamber haemocytometers (Might be able to use Birmingham's)
• Unassigned: Obtain a thermostat for the incubator
• EM: Run controls to examine how long the cells can survive vertically
• JMcG: Plan a test of vertical cell survival using Emma/Jason's HeLa cell line and Marie's cell line
• JMcG: Produce a HeLa colony that can survive on Mylar

Beamline Modelling

• Unassigned: Investigate how to improve the beamline beyond CV=8%
• CD: Examine energy spectra variation
• RW, CD: Source characterisation

Alternate Beamlines

• JMcG: Simulate BELLA
• JMcG: Simulate ELI

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