LhARA Project WPM Meeting 6th February 2024 14:00 GMT =

Meeting URL: ​​https://strath.zoom.us/j/84550543598?from=addon

Meeting ID: 845 5054 3598 Password: 737274

---

Agenda

Bridging funds

K Long - discussion - slides (here)

Bridging funds - discussion

Deliverables Work Package 1. Project management: Deliverables

• D1 Early progress review CDR M6
• D2 Interim progress review CDR M12
• D3 Pre-CDR Review M18
• D4 CDR M24

• D5 Initial progress review TDR & technical de-risk update M30
• D6 Interim progress review TDR & technical de-risk update M36
• D7 Final progress review TDR & technical de-risk update M42
• D8 Stage 1 TDR & technical de-risk report M48

• D9 Pre-TDR2 review M54
• D10 TDR2 M60

Milestones

Work package 2: Laser-driven proton and ion source

• M2.1: Prediction of optimised proton source parameters for 100+ TW laser systems based on hydrodynamic and kinetic simulations M12
• M2.2: First SCAPA ion source simulations and experiment completed M18

• M2.3: Investigation and demonstration of 10 Hz debris and damage challenges at ICL M36
• M2.4: Demonstration of continuous operation of 1 Hz beam generation on SCAPA M48

• M2.5: Demonstration of stabilised 5 Hz beam generation on SCAPA M60

Work package 3: Proton and ion capture

• M3.1: Validate plasma simulations with existing Swansea experimental set-up M6
• M3.2: Progress report of large diameter plasma experiments and simulations M18

• M3.3: Next generation plasma lens testbench design M24

• M3.4: Progress report of standalone plasma apparatus build and commissioning M36
• M3.5: Progress report of large particle-number plasma experiments and simulations M48

• M3.6: Ion focussing results M60
• M3.7: Final plasma lens design M60

Radiobiological Science and technology

Work Package 7:

• M7.1: Develop beamline and bespoke facilities at SCAPA for radiobiology experimentation M30
• M7.2: Preliminary results from cell survival/DNA damage experiments with laser-accelerated protons at SCAPA M36
• M7.3: Development of RBEs of laser-accelerated protons (versus pre-existing cyclotron-driven protons) in established cell lines M48
• M7.4: Assessment of DNA damage repair kinetics and immunopeptidomic analysis of laser-accelerated protons M48

Work package 4: Ion-acoustic dose mapping

• M4.1: Geant4 simulations of beam energy deposition profile M18
• M4.2: Acoustic sensor array design M24

• M4.3: Iterative reconstruction methods M42
• M4.4: Integration: ultra-sonic array with radiobiology station M48 may require manpower up-lift and some equipment funds
• M4.5: LhARA ion-acoustic test results M48

Work package 5: Novel end-station development

• M5.1: Design LhARA automated cell dish handling and environmental system M24
• M5.2: Report on end-station user-community consultation M24
• M5.3: Report on end-station component testing at Birmingham M24
• M5.4: Construct beam delivery room including end-station and cellular imaging capabilities M60
• M5.5: Specification of LhARA beam monitoring technology M24
• M5.6: Report on delivery of LhARA beam monitoring system M60
• M5.7: kGy/s tests at Birmingham M24

Work package 6: Design and integration

• M6.1: Final review of R&D work towards LhARA CDR M18
• M6.2: Final review of R&D work towards LhARA Phase 1 TDR M42
• M6.3: Review of R&D work towards LhARA Phase 2 TDR M48
• M6.4: Technical report on FFA main magnet prototype M58.
• M6.5: Technical report on MA RF cavity prototype M58.

Work Package 8:

• Creation of collaborative international clinical research group M40
• Wider public engagement - All party parliamentary group on radiotherapy M48

PA1

Achievements

• humble bragg competition?

WP5 consultation 3, Jan 24th Liverpool. Excellent meeting

​https://indico.stfc.ac.uk/event/923/?print=1

AOB