LhARA radiobiology; meeting: 14May26; 14:00 GMT

ZOOM: ​https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1

Meeting Agenda

Plan for PoPLaR

1. Next SCAPA beamtime
   • Dates: July/August
   • Determine a baseline/default
     • Steps required for a better repeat of cell irradiations
       • Google doc summary and Trello

2. Aim for October
   • Paper(s)?
   • What changes are required to that baseline plan for SCAPA to achieve that by October

3. Aim for Post-October
   • Desired work/papers
   • What do we need to know before we can plan more
   • What can we do pre-October to help kickstart that

3. ELI
   • Dates?
   • How does this fit into the plan

4. Review steps required
   • Share Trello

5. DoNM
   • 28/05/26

6. AoB
   • IPAC submitted

Summary of actions required

In-Beam Diagnostics

• RW, CD: Study correlation between laser diagnostics and mean dose
• CD, TP: Refine evaluations of LET in the cells with the RCF in front
• CD: Predict the cell dish dose from the RCF in front of it
• Initial measurements of sci-fi arrays
• Provide plan for Master's students who will count photons from UV source for sci-fi arrays
• PH: Investigate how to get the light out of the vacuum chamber
• Unassigned: Investigate how a phosphor sheet could be incorporated into the design of the cell dish
• Unassigned: Acquire a glass sheet

Bio Next Steps

• EM: Write up technical summary of Phase 2
• EM: Write up a future biology plan
  • Decide whether to use Marie's lab and whether to stick with HeLa
• EM, MB, JP, RA: Meet to finalise details
• CD: Gather ideas for improving cell survival
• Unassigned: Obtain an inverted microscope
• Unassigned: Obtain multi-chamber haemocytometers (Might be able to use Birmingham's)
• Unassigned: Run controls to examine how long the cells can survive vertically

Improve the spatial variation

• Decide the energy we should be optimising for
  • RW: Examine energy spectra variation
  • CD: Find LET for different energies in the cell dish
    • DONE

Other Beamlines

• JMcG: Simulate BELLA
• JMcG: Talk to ELI people and simulate ELI
• EM: Coordinate ELIMED bid

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