LhARA radiobiology; meeting: 14May26; 14:00 GMT

ZOOM: ​https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1

Meeting Agenda

Plan for PoPLaR

1. Next SCAPA beamtime
   • Dates: July/August
   • Determine a baseline/default
     • Steps required for a better repeat of the cell irradiations done previously
       • Google doc summary and Trello

2. Aim for October
   • Paper(s)?
   • What changes are required to that baseline plan for SCAPA to achieve that by October

3. Aim for Post-October
   • Desired work/papers
   • What do we need to know before we can plan more
   • What can we do pre-October to help that

4. ELI
   • Dates?
   • How does this fit into the plan

5. Review steps required
   • Share Trello

6. DoNM
   • 28/05/26

7. AoB
   • IPAC submitted

Summary of actions required

In-Beam Diagnostics

• CD, TP: Refine evaluations of LET in the cells with the RCF in front
  • DONE
• CD: Predict the cell dish dose from the RCF in front of it
  • DONE
• PH/CD: Initial measurements of sci-fi arrays
  • DONE
• CD/KL: Provide plan for Master's students who will count photons from UV source for sci-fi arrays
  • DONE
• Unassigned: Acquire a glass sheet
• Unassigned: Get a new RCF batch and calibrate
• PH: Investigate how to get the light out of the vacuum chamber
• KL/CD/JMcG/PH: Make a full scifi prototype
• RW, CD: Study correlation between laser diagnostics and mean dose
• Unassigned: Investigate how a phosphor sheet could be incorporated into the design of the cell dish

Bio Next Steps

• CD: Gather ideas for improving cell survival
  • DONE
• EM/CD/JMcG: Write up technical summary of Phase 2
• EM: Write up a biology plan for a 2 PMQ setup
• Unassigned: Obtain an inverted microscope
• Unassigned: Obtain multi-chamber haemocytometers (Might be able to use Birmingham's)
• EM*: Run controls to examine how long the cells can survive vertically

Beamline Modelling

• CD: Find LET for different energies in the cell dish
  • DONE
• RW: Examine energy spectra variation
• RW/CD: Source characterisation

Other Beamlines

• EM: Coordinate ELIMED bid
  • DONE
• JMcG: Simulate BELLA
• JMcG: Simulate ELI

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