LhARA radiobiology; meeting: 23Oct25; 14:00 BST

ZOOM: ​https://imperial-ac-uk.zoom.us/j/98220889714?pwd=SM90vOF7BKSXoU3mD9q7OwBQo4IVB3.1

Attended: CD, EM, AFr, KL, JMcG, CW, TP

Meeting Notes

1. Minutes and actions:

• RW: Fine-tune installation of cell carousel
  • Stands
• RW: Send proton numbers to Tony to get the dose rate
  • Done
• CD/DA/Afr: Find final beam setup with gold foil
  • Stands
• CD: Find alternative 8MeV setup
  • Done
• EM/JMcG/DA/more visitors: Complete the online training indicated by Mark
  • Stands
• CW/RW: Turn on and clean the water in the incubators
  • Stands
• CW: Contact Marie Boyd
  • Done Waiting
• RW: Add lip to RCF holder
  • Stands

2. Strathclyde: BT, ED, RW
   

• Dose rate updates
  • Tony and Calvin to meet with Robbie to sort this out. Invite Nick Dover as well
• Fine-tune carousel
• Incubator not turned on yet
  • Colin offered to sort it; just needs access

3. Simulation CD, DA, AFr:
   

• Results of 8MeV setup
  • 8MeV requires smaller drifts, but there are some values that fall into an acceptable range.
  • Slides
• Priority is to achieve a high dose, uniformly across the dish. Uniformity needs to be no more than 10%. Also must be uniform across the depth of the dish too, so no Bragg peaks, which means no protons entering the media with less than 1MeV.
• Set up optimisation to find the best setup to achieve this.

4. BioPrep EM, JP:
   

• Finalised irradiation plan
  • Slides
• Confirmation of plan for staining cells - when and who is needed
  • Need to have someone available on the 14th to do staining from the 5th.
  • Contact Diaza about whether he will be available
  • Contact Robbie about clearing people for weekend work in case clonogenics are done on the Thursday or Friday
  • For the clonogenic cells in the third week Emma will stain these and then bring them back to Birmingham
  • Cannot be done on the 28th so clonogenics on the third week should be aimed for Tuesday, the 18th Nov
• Marie Boyd has been contacted but no response

5. Beam Diagnostics KL, CD:
   

• RCF update
  • Trying to get as much done as possible at Imperial with Kevin
• Lip on RCF holder
  • No update
• Real-time beam diagnostic
  • Lanex cannot be placed around the cell dish as previously hoped. No room to fit the camera in.

6. DoNM

• Next Week: 30th Oct

7. AoB

• Confirm everyone has filled out the sheet and confirmed they are visiting
  • Link to the sheet: ​https://docs.google.com/spreadsheets/d/13vkixxNBZX42WFtxw7_MFJTU-gc06J19N8zpTcMKFys/edit?usp=sharing
  • Ken to determine visiting dates
  • Emma to fill out sheet but has completed training
• Visitors complete the online training indicated by Mark

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Summary of actions

• CD/DA/Afr: Find final beam setup with gold foil
• Visitors: Complete the online training indicated by Mark
• CW/RW: Turn on and clean the water in the incubators
• RW: Add lip to RCF holder
• RW/TP/CD: Meet to discuss dose rate calculation. Tony to send an email for the meeting time.
• DA: Confirm availability for staining
• CD: Confirm possibility of completing staining at the weekend
• CD: Fine-tune run plan for first week and fill out details from irradiation plan
• KL/CD: Get RCF cut